pI: 7.0982 |
Length (AA): 384 |
MW (Da): 43871 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
6 | 380 | 3c4z (A) | 163 | 527 | 21.00 | 0 | 1 | 1.15196 | 0.22 |
22 | 325 | 5lvo (A) | 74 | 356 | 36.00 | 0 | 1 | 1.20207 | -0.91 |
28 | 340 | 4aw2 (A) | 75 | 372 | 39.00 | 0 | 1 | 1.2819 | -0.89 |
30 | 328 | 2z7q (A) | 62 | 340 | 45.00 | 0 | 1 | 1.09145 | -0.35 |
120 | 177 | 4oav (B) | 438 | 507 | 36.00 | 0.033 | 0.93 | 0.544842 | -0.23 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Trophozoite, Rahman HM-1 IMSS Trophozoite. | Hon CC |
Hon CC | Transcriptomics of virulent and avirulent strains |
Ortholog group members (OG5_129514)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G58140 | phototropin 2 |
Arabidopsis thaliana | AT3G45780 | phototropin 1 |
Candida albicans | CaO19.7854 | potential Ser/Thr protein kinase similar to S. cerevisiae YNR047 |
Candida albicans | CaO19.223 | Serine/threonine protein kinase |
Dictyostelium discoideum | DDB_G0276157 | MAST family protein kinase |
Entamoeba histolytica | EHI_044640 | protein kinase, putative |
Giardia lamblia | GL50803_221692 | Hypothetical protein |
Leishmania braziliensis | LbrM.25.1930 | serine/threonine-protein kinase, putative,protein kinase, putative |
Leishmania donovani | LdBPK_252450.1 | AGC essential kinase 1 |
Leishmania infantum | LinJ.25.2450 | serine/threonine-protein kinase, putative,protein kinase, putative |
Leishmania major | LmjF.25.2340 | serine/threonine-protein kinase, putative,protein kinase, putative |
Leishmania mexicana | LmxM.25.2340 | serine/threonine-protein kinase, putative,protein kinase, putative |
Oryza sativa | 4351240 | Os12g0101800 |
Oryza sativa | 4349531 | Os11g0102200 |
Oryza sativa | 4335426 | Os04g0304200 |
Saccharomyces cerevisiae | YNR047W | Fpk1p |
Saccharomyces cerevisiae | YCR091W | Kin82p |
Trypanosoma brucei gambiense | Tbg972.3.2430 | serine/threonine-protein kinase, putative,protein kinase, putative |
Trypanosoma brucei | Tb927.3.2440 | AGC essential kinase 1 |
Trypanosoma congolense | TcIL3000_3_1480 | AGC essential kinase 1 |
Trypanosoma cruzi | TcCLB.508479.150 | AGC essential kinase 1 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.2440 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.2440 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.2440 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.2440 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 25.0% | 308 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 24.6% | 313 aa | Compounds | References |
Bos taurus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 35.1% | 322 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 25.4% | 319 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 23.9% | 314 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 25.3% | 328 aa | Compounds | References |
Oryctolagus cuniculus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 34.2% | 322 aa | Compounds | References |
Rattus norvegicus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 35.1% | 322 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 28.6% | 210 aa | Compounds | References |